Applications LioniX BV, part of a Micro/Nano Technology company group of 70 people, including iX-factory GmbH in Dortmund, is a global leading provider in development and production for its customers in Tele/datacom, Life Sciences, Process Control and Space. The customers include innovative OEM’s, VC-funded start-up companies, multi-national corporations, and research institutions. The core technologies of LioniX include integrated optics, micro/nanofluidics and related surface functionalization. http://www.lionixbv.nl Sat, 27 Sep 2014 17:10:55 +0200 Joomla! - Open Source Content Management en-gb Lab-on-a-Chip http://www.lionixbv.nl/applications/app-lab-on-a-chip.html http://www.lionixbv.nl/applications/app-lab-on-a-chip.html Lab-on-a-Chip

A Lab-on-a-Chip (LoaC) is a device that integrates one or several laboratory functions on a single chip of only square millimeters to a few square centimeters in size. LoaCs are based on micro-fluidics technology and deal with the handling of extremely small fluid volumes with pico-liter accuracy.

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Value Proposition

In the last decade LioniX build up a large experience in the realization of LoaC devices and the revolutionizing potential of LoaC-based systems is widely recognized in Life Sciences, Industrial Process Control and Space. The ability to perform analysis with small volumes of reagents has a direct cost advantage. Compact LoaC devices, realized in the proprietary (optofluidic) LioniX technology, enable faster mixing and heating, reduced consumption of reagents, better control of processes, and the potentially high degree of automation. As a result, innovative R&D equipment based on LoaC has been introduced rapidly the last decennium.

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Solutions

LioniX built up an extensive know how in LoaC technology in the last years and our (optofluidic) technology enables new applications resulting in customers and partners in a variety of application areas (e.g):

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  • LoaC for Biotechnology R&D
  • Medical Applications like rapid screening and gas sensors
  • Drug discovery and development

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LioniX is co-developping (reusable) LoaC based diagnostic systems, allowing economical feasible applications.
Combination of multiple functions in a miniaturized, dedicated automated system is a compelling argument to have LoaC technology accepted beyond the R&D laboratories. A good example of this is being exploited in the Life Marker Chip instrument (LMC), planned as being the key instrument to detect signs of past life, i.e. biosignature molecules on Mars in the ExoMars mission os the European Space Agency (ESA), scheduled for 2018. (Unfortunately the LMC had to be ‘descoped’ after a development of 8 years because of the withdrawal of NASA in this mission in 2012. The instrument payload had to be reduced as a result of a (much) smaller rover that ESA is able to develop in the new collaboration with the Russian space agency.)
It is a LoaC based analysis platform for many non-space applications as well and moreover a shining example of LioniX unparalleled expertise in optofluidics.

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jan.lucas@jlink.nl (Super User) Applications Mon, 02 Jan 2012 13:43:15 +0100
Flow Chemistry http://www.lionixbv.nl/applications/app-flow-chemistry.html http://www.lionixbv.nl/applications/app-flow-chemistry.html Flow Chemistry

Over the past decade a new way of doing chemistry has emerged: chemical synthesis in continuous flow instead of batch manufacturing. Working closely with start-up companies in this field such as ChemtriX BV, LioniX has developed the necessary technology to design and manufacture micro reactors.

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Value Proposition

The expertise of LioniX in microfluidics enables the design and realization of complex state of the art fluidic components for micro-reactor technology. In these devices syntheses can be performed in a pressurized system, over a wide temperature range enabling facile access to extreme reactions conditions. Adding our expertise in integrated optics to our micro-reactor technology enables the continuous monitoring of chemical reactions.

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Solutions

Labtrix® and PlantriX®

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Based on the fluidic technology of LioniX several different micro reactor devices were developed and realized for the product portfolio of ChemtriX. We were the first to show scalability of the flow chemistry concept going from milligrams of chemical component manufacturing in small 1 * 1 cm chips (Labtrix®) to kilograms in a large 15 cm by 15 cm chip (PlantriX®) without the need to adapt the process parameters. Labtrix® is a laboratory system on which flow chemistry method development is performed prior to using Plantrix® for tonne scale production.
For more information see ChemtriX BV website.

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jan.lucas@jlink.nl (Super User) Applications Thu, 08 Sep 2011 15:13:51 +0200
Sensing Systems for Process Control http://www.lionixbv.nl/applications/app-sensing-systems.html http://www.lionixbv.nl/applications/app-sensing-systems.html Sensing Systems for Process Control

Enhancements of sensing systems and flow manifolds for fluid control in manufacturing processes, chemical synthesis and analysis systems build on new innovations in microtechnology. Batch processing of sensors enable high volume manufacturing of identical sensors that are used for Industrial Process Control (IPC).

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Value Proposition

Current trends and developments, enabled by micro technology, are miniaturization, parallelization and pressurization, resulting in better performance, less reagents consumed and enabling of faster reactions, for example to arrange processes in a flow-through arrangement rather than in a batch arrangement. Micro technology provides a solution for these developments. LioniX offers integration and customization of key components and technologies, such as flow manifolds, flow sensors, thermal sensors and valves.

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Solutions

Several co-development projects have resulted in effective solutions for our customers, to highlight a few:

  • Sensitive IQ+ flow sensor for Bronkhorst Hi-Tech
  • Conductivity datalogger for Onset for continuous monitoring of fluids
  • Flow manifold for Life Marker Chip (LMC) development, scheduled for European Space Agency (ESA) MARS expedition in 2018
  • pH ISFET sensors for various customers

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jan.lucas@jlink.nl (Super User) Applications Thu, 08 Sep 2011 14:35:28 +0200
Optical Sensing Systems http://www.lionixbv.nl/applications/app-optical-sensing-systems.html http://www.lionixbv.nl/applications/app-optical-sensing-systems.html Optical Sensing Systems

Optical sensors can provide very high sensitivity, wide dynamic range and immunity to electrical interference. In case of using Integrated Optics (IO), also miniaturization and remote sensing becomes possible. When based on our proprietary TriPleX™-platform, these IO-sensors can be easily combined with micro-fluidics, yielding so-called opto-fluidics.

Value Proposition

LioniX is world leader in IO sensing systems, ranging from fluorescence based, through absorption based, to interference based sensing geometries. LioniX combines Silicon and fused silica substrates in their microfluidics designs to provide the most a cost effective solution. In the case of using Silicon as substrate, PIN Si-detectors and even Si-based lightsources can be integrated in the substrate, allowing a broad range op applications.

Solutions

Examples of integrated optical sensors, suitable for hybrid or monolithic combination with microfluidic systems, are based on:

  • Changes in the fluorescence
  • Refractive index change
  • Absorption properties of the fluid

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A good example of opto-fluidics as educational tool is the complete opto-fluidic analysis system for Saxion University of Applied Sciences in Enschede. The system is designed by LioniX, used in the bachelor program “Nanotechnology” and enables an easy accessible method for acquiring deeper insight in integrated optics and micro-fluidics. The system combines the LABTRIX micro reactor from ChemtriX BV with the Hyperion laserbox of XiO Photonics and at its core a fused silica based opto-fluidic microchip manufactured by LioniX. The integrated microchip enables online monitoring, and therefore direct optimization of the micro reactor product using absorption based evanescent field detection.

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The Hyperion uses an Integrated Laser Beam Combiner (ILBC) to combine 3 different wavelengths (488, 532, 635 nm) into a single output fiber. This allows analysis of the micro reactor substance inside the opto-fluidic microchip using a wide range of wavelengths.

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Laser beam combining for optical microscopy is a promising visible light application enabled by compact photonic chips.

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gerrit@fairwater.nl (gerrit) Applications Fri, 17 Feb 2012 18:58:37 +0100
Optical Circuitry & Communications http://www.lionixbv.nl/applications/app-optical-circuitry-communications.html http://www.lionixbv.nl/applications/app-optical-circuitry-communications.html Optical Circuitry & Communications

Microwave Photonic Filters (MPFs) and the optical generation of microwave signals, as two major applications of microwave photonics research, have recently attracted much attention.

LioniX provides TriPleX™-based technology that enables compact integrated microwave-photonics-functionality on a silicon-platform, so called Optical Beam forming Networks (OBFN). The technology enables fabrication of compact beamforming networks for smart antenna arrays.

Also telecommunication functions like DWDM modules and routers are using the unique broadband TriPleX™ properties for small footprint high volume chip manufacturing. In order to make the next step in integrated optics more complex structures need to be developed based on the photonic platform. Based on building blocks in the proprietary TriPleX™ technology complex Very Large Scale Integration VLSI in integrated optics can be realized in a large variety of applications.

Value Proposition

LioniX TriPleX™-based technology enables compact integrated waveguide structures which are low loss and transparent over a large wavelength range (from UV to IR). Designs on system level can be made by utilizing developed building blocks in a more complex geometry allowing more complex component design for new applications. Based on this technology LioniX is strategic supplier of this technology to several end users and also an enabling partner in several R&D Projects for low loss photonic (communication) applications.

Solutions

The low loss properties of the TriPleX™ technology make it suitable for a broad range of applications for various wavelengths. Two examples in different wavelength regimes are given below:

MicroWave Photonics:

Microwave Photonic Filters (MPFs) and the optical generation of microwave signals, as two major applications of microwave photonics research, have recently attracted much attention. The TriPleX™ technology enables fabrication of compact beamforming networks for smart antenna arrays.

These Smart Antenna systems are being developed to enable efficient and cost-effective satellitecommunication to spacecraft and airliners. In such systems, optical Beam-Forming Networks based on an all-optical True-Time Delay offer improved bandwidth performance over electronic phase-shifters. The frequency independence of an all-optical True-Time Delay enables a simpler, less expensive control system and improves overall system performance.

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LioniX is strategic supplier of this technology to SATRAX and enabling partner in the Point One R&D Project “Broadband satellite communication services on high-speed transport vehicles”.

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For more information see SATRAX website.

Visible Light Applications:

The transparency over a large wavelength range (from 400nm to 2.35 µm) makes the TriPleX™ technology very suitable for a variety of applications. The waveguide design can be tailored to a specific spectral window realizing low-loss singlemode waveguides over a large wavelength range. Based on the TriPleX™ technology beam combiners are realized by XiO Photonics for applications in the visible light regime (for instance laser induced fluorescence).

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For more information see XiO Photonics website.

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jan.lucas@jlink.nl (Super User) Applications Thu, 04 Aug 2011 18:16:29 +0200
Foundry Services http://www.lionixbv.nl/applications/app-foundry-services.html http://www.lionixbv.nl/applications/app-foundry-services.html Foundry Services

LioniX provides foundry services ranging form single step services as well as processing of complex structures and components. Our foundry services are performed by LioniX engineers on the Nanolab equipment from the MESA+ Research Institute. In addition LioniX has its private cleanroom facilities with equipment for our proprietary technologies.

Value Proposition

LioniX MEMS and microtechnology services are particularly useful for companies developing MST/MEMS-based products, but who fail the access to critical technologies for small volume manufacturing or prototyping. LioniX experiences a particular influx from applications which are developed by telecom startups, life science, Industrial Process Control (IPC) equipment manufacturers and research institutes. Our processes are performed on silicon, SOI, borosilicate, fused silica and other substrates, preferably on 100 mm wafers but other sizes are possible as well. We work with carefully selected wafer manufacturers who deliver on request single/double side polished, different doping levels, roughness, bow/warp. You can also ship your own wafers, blank or processed.

Solutions

Based on the foundry processes of LioniX a variety of applications is realized. The majority of these applications cannot be disclosed due to confidentiality, but a small overview is given below:

Examples of membranes
  • Sensors that use the thermal profile of a heated membrane to sense a small mass flow. These membranes are equipped with metallic thermocouples
  • Massive arrays of membranes are equipped with capacitive electrodes to allow acoustic sensing and actuation to allow sensing with unprecedented resolution
  • Ultra-thin 8nm (World Record) TEM grids
Examples of devices withthrough wafer holes
  • Ion mobility spectrometer
  • Micro and nano sieves allow for high throughput micro and nano particle generation
Examples of complex MEMS structures
  • Different types of Scanning Probe Microscopy (SPM) tips require complex MEMS processing. Lionix develops tips with channels that allow precise application of droplets as well as tips with multiple probes that allow resistivity mapping with ultra high resolution
  • Chemical sensors : ISFET CHEMFET Clark electrodes
  • Functional membranes of Wool, Poly Propylene, celluloses, Anapore, PVDF
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jan.lucas@jlink.nl (Super User) Applications Thu, 08 Sep 2011 17:23:32 +0200